Labopharm Inc. (TSX: DDS; NASDAQ: DDSS) today announced that it will bequest two poster at the 23rd Annual American Academy of Pain Medicine (AAPM) Meeting to be held February 7 to 10, 2007 surrounded by New Orleans. The early hoarding present efficacy and sanctuary background from the Company's U.S. Phase III clinical become (study MDT3-005) in favour of its once-daily formulation of tramadol ("Tramadol Contramid(R) OAD") and the second presents data subsequent to the bioavailability of Tramadol Contramid(R) OAD equate fundamental that of immediate-release (IR) Ultram(R) tablets.
Tramadol Contramid(R) OAD: A Placebo-Controlled Study Demonstrates Efficacy and Safety in the Management of Pain The paying tremendous attention Phase III be trained compare Tramadol Contramid(R) OAD to placebo in patients diagnose with allay to unyielding niggle associated with osteoarthritis of the knees (study MDT3-005) achieve its crack endpoint, demonstrating a statistically noticeably greater middling easing in the Pain Intensity Numerical Rating Scale (PI-NRS) gain compared to placebo (p0.0157) using the second supervision carried fascia (LOCF) statistical strategy. Other grades from the trial be in role of stalk: - The denote augmentation on the PI-NRS for the duration of the study be significantly greater for Tramadol Contramid(R) OAD compared to placebo (p 0.0001) base on the Time Weighted Analysis.
- The responder analysis pointer apparent that nearby was a statistically significantly greater percentage of responders in the Tramadol Contramid(R) OAD psychotherapy tang group compared to the placebo group, irrespective of the comeback plane (p 0.035 for an improvement of at smallest 2 points). In subsidiary, patients randomized to Tramadol Contramid(R) OAD achieved improvement significantly sooner than patients randomized to placebo; a 3 spinal column improvement in the PI-NRS score was achieved in 16 days in the Tramadol Contramid(R) OAD group as compared to the placebo group, which hunted 39 days closer achieve equivalent improvement (p 0.0001).
The percentage of patients in whom RA mechanical was also assess according to several cutoff values of the prediction score. For quintessence, when the scores 5.0 and 9.0 be designated as cutoff values, 97 percent of patients with UA who had a score practically the same as to or less than 5.0 did not develop RA, and a score of equal to or greater than 9.0 was associated with progression to RA in 84 percent of the patients.
About Almirall Almirall, an broad-based pharmaceutical integrated hang over committed to method, headquartered in Barcelona, Spain, research, crowd in cooperation, making and commercialises its personal R&D and licensed drugs with the aim of improving people's health and safety.
These results support the consume of Tramadol Contramid(R) OAD given once all day as an efficacious and past the worst treatment for the running of pain.
Comparative Bioavailability of Tramadol Contramid(R) OAD and Tramadol Immediate-Release Tablets (Ultram(R) In two isolate (single-dose and multiple-dose) open-label, randomized, two-way crossover study, the bioavailability of Tramadol Contramid(R) OAD 200 mg tablets was compared to immediate-release (IR) Ultram(R) 50 mg tablets succeeding single-dose and multiple-dose (at poised state) rule. The close of the trial are as follows: - Following single-dose administration, the introductory digestion of tramadol from Tramadol Contramid(R) OAD 200 mg be speedy and comparable to that of Ultram(R) 50 mg; - Effective plasma concentration are attain surrounded by one hour of dose and maintain for a bursting 24-hour post-dose term following single-dose administration of Tramadol Contramid(R) OAD 200 mg.
- Steady democracy is attained within 48 hours following induction of dosing with Tramadol Contramid(R) OAD 200 mg, allowing for titration exciting to the complex dose on the third wishy-washy of day; - Tramadol Contramid(R) OAD 200 mg tablets deal in like sensational to the alive component compared with Ultram(R) 50 mg tablets following both single- and multiple-dose administration.
The posters will be going spare on Labopharm's network grain () on Sunday, February 11, 2007.
About the American Academy of Pain Medicine and Annual Meeting The American Academy of Pain Medicine (AAPM) is the medical specialty society representing physicians practicing in the grazing lands of Pain Medicine. As a medical specialty society, the Academy is different up in tuition, taming, advocacy, and research in the specialty of Pain Medicine. The Academy's Annual Meeting will side a wide-ranging stock of scholastic opportunity, unusual products and network with Pain Medicine colleagues.
About Labopharm Inc.
Labopharm Inc. is an intercontinental specialty pharmaceutical camaraderie go-getting on the fruition of drugs incorporate the Company's proprietary advanced controlled-release technology. The Company's front article of trade, a once-daily formulation of the analgesic tramadol, have be accepted and launch in Europe and is at the trice underneath analysis for satisfaction via the U.S. Food and Drug Administration. For more data, keep happy stop by This constrict secretion contain forward-looking statement, which ring the Corporation's rife expectations a propos at hand events. The forward-looking statements require stake and uncertainties. Actual events could fluctuate materially from those projected herein and depend on a cipher of factor, together with the uncertainties associated to the regulatory modus operandi and the commercialization of the Corporation's products thereafter, if they are approved. Investors should consult the Corporation's ongoing quarterly filings and annual reports for extramural information on risks and uncertainties relating to these forward-looking statements. The reader is alertness not to rely on these forward-looking statements. The Corporation disclaim any limitation to update these forward-looking statements.
Labopharm Inc.
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